The DNA test verifies the presence of the affected allele at PLOD1 locus responsible for WFFS
- 20 to 30 - hair roots - envelope
- 5 mL - blood - K3 EDTA tube
- 2 to 5 working days
The genetic test verifies the presence of the affected allele at PLOD1 locus responsible for WFFS and the presents results as one of the following:
- N/ - Negative for WFFS. Absence of the affected allele at PLOD1 locus responsible for WFFS.
- N/WFFS - Positive heterozygous for WFFS. Presence of a mutated allele at the PLOD1 locus responsible for WFFS. The horse is affected with the WFFS and can pass the WFFS1 allele to 50% of their progeny when bred.
- WFFS/ - Positive homozygous for WFFS. Presence of two mutated alleles at the PLOD1 locus responsible for WFFS. The horse is affected with the WFFS and will pass the WFFS allele to 100% of its offspring.
Warmblood Fragile Foal Syndrome WFFS is an inherited autosomal disorder caused by a single mutation in PLOD1 gene.
WFFS has been identified in a population of horses known as Warmbloods. Primarily originating in Europe during the Middle Ages, Warmblood horses were the result of breeding large cold blood draft horses of northern Europe with hot blooded, lighter and faster Arabian horses that warriors captured in the Middle East and Africa and brought back with them after their battles.
As a result Warmbloods are a group of mid-sized horse types often called Sport Horses and developed with the aim of competing in Olympic equestrian sports.
Warmblood Fragile Foal Syndrome (WFFS) is an inherited systemic connective tissue disorder that is prevalent in Warmblood horses.
Skin lacks tensile strength (extreme skin fragility characterised by tearing, ulceration, etc. from contact with normal surroundings). Lesions occur anywhere on the body, but are most noted on pressure points and in addition to skin wounds, lesions are found on the gums and other oral cavity mucous membranes and the perineum. Limb joints are lax and hyper-extensible. Fetlocks are the most dramatically affected and affected foals cannot stand normally.
Affected foals must be euthanised soon after birth.