A One-Stop Lab for Horse Diagnosis

Myopathy Plan

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Mypophaties are a frequent cause of muscle tremors and paresis. Many different muscle disorders have been attributed to genetic disorders, infectious and metabolic syndromes. 

This plan include testing for the most common horse myopathies: 

  •  3 genetic diseases - PSSM1, HYPP and IMM;  

  • 2  infectious agents - Equine protozoal myeloencephalitis (EPM) and Streptococus equi;

  • 3 metabolic syndromes - nutritional myodegeneration, seasonal pasture myopathy, metabolic abnormalities in calcium, magnesium, potassium and muscle enzymes activities 


Tests performed Affected breed Clinical Signs Metabolic  Management Type

PSSM1 Polysaccharide Storage Myopathy type 1.

more info

 Different breeds. Quarter horses related breeds (8%) , Belgians (50%),  Draft and Warmblood.

Muscle damage: Reluctance to move with light exercise. Skin twitching, stiffness, painful muscles, sweating, weakness.  

May occur: Gait abnormalities, mild colic and muscle wasting.

Muscle enzymes activities increased. In some cases mild to moderate increases.

 Diet (low-starch and low-sugar)  and exercise regimens.

Ask your veterinarian

Genetic disorder/dominant autosomal.

SNP @ GYS1 locus  

HYPP Hyperkalemic Periodic Paralysis 

more info

 Quarter horse related breeds

Myotonic disorder: muscular irritability, contractility, and delayed relaxation. Unpredictable paralysis attacks that can lead to sudden dead.

Other myotonic disorder is the Congenital Myotonia (CM)  of New Forrest Pony. For more info about CM

Normal muscle enzyme activities but increased potassium level

Handling of clinical episodes/  Prevention of future attacks  (tranquillisation and/or others)/ Diet and Exercise regimens.

Ask your veterinarian

Genetic disorder/dominant autosomal.

SNP @ SCN4A locus

IMM    Immune Mediated Myositis   Quarter horse related breeds

Muscle damage (muscle wasting, stiffness and weakness) triggered by infection and/or vaccination.


Genetic disorder/dominant autosomal.

SNP @ MYH1 locus