MIM (PSSM2) DNA Test
Ensure the Health and Performance of Your Horses with Accurate MIM Testing. Our DNA test identifies the presence of genetic variants associated with Muscle Integrity Myopathy (MIM), formerly known as PSSM2, which affects muscle function and structure.
Sample Requirements
- 30 to 40 hair roots - envelope
- Alternatively, 5 mL blood - K3 EDTA tube
Turnaround Time
- up to 15 working days
Results Description
The DNA test identifies six genetic variants that predispose horses to developing symptoms of Muscle Integrity Myopathy:
- P2: Myotilinopathy
- P3: Filaminopathy
- P4: Myozenin-3-Myopathy
- P8: PYROXD1-Myopathy
- Px: CACNA2D3-Myopathy
- K1: COL6A3-Myopathy
Genetic Inheritance
Muscle Integrity Myopathy (MIM) is caused by a hereditary predisposition involving multiple genetic variants. These variants disrupt the structure and function of muscle fibers, leading to symptoms such as muscle stiffness, unexplained lameness, and difficulty building muscle.
Clinical Signs and Affected Breeds
Symptoms of MIM can vary widely among horses and include unexplained lameness, muscle stiffness, difficulty with gait changes, reluctance to move, muscle atrophy, and behavioral changes. Almost any breed can be affected, with common occurrences in breeds like Quarter Horses, Warmbloods, and Thoroughbreds.
Why Test?
Testing for MIM is crucial for breeders and owners to make informed decisions. By identifying carriers of the genetic variants, breeding choices can be optimized to prevent the spread of these disorders. Additionally, knowing a horse's genetic status can help manage and mitigate symptoms through tailored exercise and feeding protocols.